Statistics for occurrence #1 of “Ohio River” in chapter 13 of John G. Nicolay, The Outbreak of Rebellion:

... the Blue Ridge, then to the main Appalachian chain; west of the dividing crest, the country retains its mountainous characteristics, a succession of ridges and a medley of hills, till it reaches the Ohio River . Not alone through earlier settlement, but also by reason of climate, soil, and situation, East Virginia remained the region of large plantations, heavy slave population, and profitable agriculture...
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