Statistics for occurrence #1 of “Miss Mary C. Breckenridge” in chapter 9 of Thomas Wentworth Higginson, Harvard Memorial Biographies:

... graduating in 1845. After this, he spent several years in Europe, as a student at the Universities of Heidelberg, Berlin, and Breslau. On his return, in 1852, he married (March 30th) his cousin, Miss Mary C. Breckenridge , a lady greatly respected and beloved by all who knew her, but who was taken from him by death in the short space of two years. In 1855 he returned to Europe, spending the winter at Ems and Paris. ...
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