Statistics for occurrence #1 of “Dr. Holmes” in chapter 3 of Thomas Wentworth Higginson, Olde Cambridge:

...derwood, when I expressed delight at the first number, seemed very glad to have me say it, because there was, as he said, a minority of readers, who were disposed to pooh-pooh it, and maintained that Dr. Holmes was a tiresome little man. This was perhaps only the natural Nemesis encountered by a joker of many years' standing; at any rate all such malcontents soon passed into oblivion and were heard no mo...
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