Statistics for occurrence #1 of “Mrs. Holmes” in chapter 21 of Charles E. Stowe, Harriet Beecher Stowe compiled from her letters and journals by her son Charles Edward Stowe:

...n of the Messiah's mission, when God shall wipe all tears away. My face is set that way, and yours, too, I trust and believe. Mr. Stowe sends hearty and affectionate remembrance both to you and Mrs. Holmes , and I am, as ever, truly yours, H. B. Stowe. About this time Mrs. Stowe paid a visit to her brother Charles, at Newport, Fla., and, continuing her journey to New Orleans, was made to feel ho...
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