Statistics for occurrence #1 of “Mrs. Stowe” in chapter 23 of Charles E. Stowe, Harriet Beecher Stowe compiled from her letters and journals by her son Charles Edward Stowe:

...this revelation . Hoping that you have recovered from your indisposition, I am Faithfully yours, O. W. Holmes. While undergoing the most unsparing and pitiless criticism and brutal insult, Mrs. Stowe received the following sympathetic words from Mrs. Lewes (George Eliot):-- The Priory, 21 North Bank, December 10, 1869. My dear friend,--. . . In the midst of your trouble I was often thinking ...
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