Statistics for occurrence #1 of “Mrs. Agassiz” in chapter 17 of Laura E. Richards, Maud Howe, Florence Howe Hall, Julia Ward Howe, 1819-1910, in two volumes, with portraits and other illustrations: volume 1:

... in 1875. Considering this brave showing, it is strange to recall the great fight before the barred doors of the great universities. The women knocked, gently at first, then strongly: our mother, Mrs. Agassiz , and the rest. They were greeted by a storm of protest. Learned books were written, brilliant lectures delivered, to prove that a college education was ruinous to the health of women, perilous to...
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