Being commissioned Major General, and on the eve of embarking at the head of an expedition fitted out by the English against Carthegena, in South America, Spotswood died at Annapolis, Maryland, June 7, 1740. Governor Spotswood and Ann Butler, his wife, had four children: (1) John, (2) Ann Catherine, (3) Dorathea, (4) Robert.
（1) John married (1745) Mary, daughter of William Dondridge, Esq., of Elson Green, King William, Va., a captain in the British navy.
（3) Dorathea married (1747) Colonel Nathaniel West Dandridge, a full brother of her sister-in-law, Mrs. John Spotswood. Mrs. Dorathea Dandridge died in 1773, in the forty-sixth year of her age.
（4) Robert was a subaltern officer under Washington.
In 1756,. while with a scouting party, he was killed near Fort du Quesne.
XIV.--Ann Catherine married Colonel Bernard Moore, of Chelsea, King William county, Va., a gentleman seventh in descent from Sir Thomas Moore, of Chelsea, England, the author of Utopia.