Frank Preston Stearns, Cambridge Sketches

Nature commonly sets her own stamp on the face of a humorist. The long pointed nose of Cervantes is indicative of immeasurable fun, and there have been many similar noses on the faces of less distinguished wits. Doctor Holmes ridiculed phrenology as an attempt to estimate the money in a safe by the knobs on the outside, but he evidently was a believer in physiognomy, and he exemplified this in his own case. His face had a comical expression from boyhood; its profile reminded one of those prehistoric images which Di Cesnola brought from Cyprus. As if he were conscious of this he asserted his dignity in a more decided manner than a man usually does who is confident of the respect of those about him. Thus he acquired a style of his own, different from that of any other person in Boston. He was not a man to be treated with disrespect or undue familiarity.

A medical student named Holyoke once had occasion to call on him, and as soon as he had introduced himself Doctor Holmes said: “There, me friend, stand there and let me take an observation of you.” He then fetched an old book from his library which contained a portrait of Holyoke's grandfather, who had also been a physician. He compared the two faces, saying: “Forehead much the same; nose not ”