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αὐτοῦ: poss. gen., to be closely connected with τοῖς πολίταις (“his fellow-citizens”).

μὴ ὀνήσει: the generic idea causes the negative μή.

τοὐναντίον: is certainly adverbial, and to be attached to ἔλαττον (ὀνήσει). The sense of this difficult passage seems to be something like this: “What advantage is there in giving to a sick man anything which cannot profit him, more or less”; literally, “sometimes more, or on the contrary, at least rightly considered, less.”

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